A pioneer in biotechnology Har Gobind Khorana is credited with making the first synthetic genes by cutting and pasting DNA bits Jacob Koshy Who was Har Gobind Khorana? Nobel Laureate Har Gobind Khorana’s contributions to biology are of contemporary relevance for some of the most exciting areas such as synthetic biology and gene editing. A Google Doodle on Tuesday to mark the 96th birth anniversary of the Indianorigin American scientist this week stoked much interest in his work. What were his contributions to biology? After James Watson and Francis Crick found that DNA (Deoxy ribonucleic acid) had a doublehelix structure, Khorana was among thos...
Expanding the donor pool Indian scientists develop mechanism to rejuvenate aged stem cells I n cases such as bone marrow transplantation, which involves the transplantation of hematopoietic stem cells, namely stem cells that give rise to other types of blood cells, a younger donor age results in a better outcome. A group of Indian scientists have now developed a mechanism that can rejuvenate stem cells from older donors, making them useful for transplantation. The mechanism development by researchers at the National Centre for Cell Science (NCCS), Pune, involves rejuvenating aged hematopoietic stem cells in a shortterm culture using microvesicles secreted by young stromal cells. This approach, they hope, will expand donor cohort. The fnding has relevance in clinical bonemarrow transplantation, wherein aged donors are usually not preferred as their stem cells...
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